Detalhe da pesquisa
1.
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Cell
; 171(6): 1437-1452.e17, 2017 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29195078
2.
Chemically targeting the redox switch in AP1 transcription factor ΔFOSB.
Nucleic Acids Res
; 50(16): 9548-9567, 2022 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36039764
3.
Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA).
Mol Cell Neurosci
; 99: 103386, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31202891
4.
Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis.
Proc Natl Acad Sci U S A
; 114(22): E4462-E4471, 2017 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-28500272
5.
Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function.
J Biol Chem
; 290(23): 14361-80, 2015 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25878248
6.
Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.
Bioorg Med Chem Lett
; 26(4): 1265-1271, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26804233
7.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
Bioorg Med Chem
; 24(18): 4008-4015, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27377864
8.
CIPC is a mammalian circadian clock protein without invertebrate homologues.
Nat Cell Biol
; 9(3): 268-75, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17310242
9.
A screen for regulators of survival of motor neuron protein levels.
Nat Chem Biol
; 7(8): 544-52, 2011 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21685895
10.
Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration.
ACS Chem Neurosci
; 12(2): 271-284, 2021 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33417763
11.
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation.
Neuron
; 52(2): 255-69, 2006 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17046689
12.
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.
J Am Chem Soc
; 132(47): 16962-76, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21067169
13.
Deep Learning Benchmarks on L1000 Gene Expression Data.
IEEE/ACM Trans Comput Biol Bioinform
; 17(6): 1846-1857, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-30990190
14.
Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate.
J Med Chem
; 63(5): 2638-2655, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31825616
15.
Discovery of suppressors of CRMP2 phosphorylation reveals compounds that mimic the behavioral effects of lithium on amphetamine-induced hyperlocomotion.
Transl Psychiatry
; 10(1): 76, 2020 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32094324
16.
An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration.
Cells
; 8(12)2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31783699
17.
Structural Basis for Achieving GSK-3ß Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.
J Med Chem
; 62(21): 9600-9617, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31535859
18.
High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology.
Nat Commun
; 9(1): 5142, 2018 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30510233
19.
Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory.
ACS Chem Neurosci
; 9(9): 2262-2273, 2018 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29932631
20.
Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling.
Transl Psychiatry
; 8(1): 135, 2018 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046097